Between 1 January and 27 September 2022, a total of 25,932 confirmed dengue cases and 62 deaths (CFR 0.25%) were reported in Pakistan, with 74% of these cases reported in the month of September alone. The current surge in cases follows unprecedented flooding that began in mid-June 2022. With the current flood crisis affecting the national health system capacity and the growing humanitarian situation, there is a high risk of serious health impacts from dengue fever and other concurrent disease outbreaks. High population movement between Pakistan and bordering countries (in particular, Afghanistan and the Islamic Republic of Iran) means that the international transmission of dengue fever cannot be ruled out.